Single Cell Analysis Market Professional Survey Report Trends, Growth Rate, Segment And Forecasts To 2026
Single cell analysis
is an emerging technology that helps sequence whole human genome at a
single cell level. This particularly includes genomics,
transcriptomics, proteomics, epigenomics, and metabolomics with its
sensitivity improved to single cell level. In genomics, new
generation methodologies such as next generation sequencing and third
generation sequencing play crucial roles. The aim of single cell
analysis is mainly to measure and analyze cellular heterogeneity.
Single cell analysis interpret life at fundamental level and find
immense applications in the field of medicine. Single cell analysis
over conventional standard cell numbers sequencing method enable the
discovery and investigation of unknown micro-organisms.
A study published in
the Journal of Single Cell Analysis 2014, stated that a variety of
technologies that are powerful and less expensive, such as Multiple
Annealing And Looping-Based Amplification Cycle (MALBAC) and Multiple
Displacement Amplification (MDA), find great progress in uncovering
somatic mutations in human genome and detection of copy number
variation. But in human single-cell genomics, Whole Genome Sequencing
or Whole Exome-Sequencing (WGS or WESseq) finds great potential in
clinical applications, especially in screening, diagnosis, and
monitoring. It is popular in academic research because mRNA helps
bridge genome structure and epigenomics modification with phenotype,
reveals gene functions and regulatory network, and most importantly
it is easier to perform than proteomics.
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Inclination toward
single-cell technology by biologists is mainly because many samples
including stem cells, immune cells, neurons, cancers, and other
tissues exhibit a stochastic nature with heterogeneity factor.
Conventional methods cannot provide transcriptomic profile in highly
heterogeneous cell population. Even if cell population is less,
single cell analysis can enable the identification of biomarkers of
delicate phenotypes or disorders (e.g. cancer stem cells). In
addition, this analytical technique also helps classify different
cell types in different physiological and pathological conditions, in
very rare events of any somatic mutation, epigenetic modification of
regulatory gene expression, and its function.
Global
Single Cell Analysis Market Taxonomy
The global single
cell analysis market is segmented on the basis of product, types of
cells, type of technique, application, and end user.
By
product:Consumables (beads, microplate, reagents, assay
kits, etc.), Instruments (PCR, NGS system, spectrophotometers, etc.),
Automated, Manual
10x Genomics, in
2017, launched the chromium single cell V(D)J solution for profiling
full length paired V(D)J transcripts from hundreds to millions of
lymphocyte. It is a reagent system, which has the ability to
completely identify and characterize T and B cells by single cell
sequencing. This will reveal true clonality and diversity in adaptive
immune system. This product will have an impact on research based
single cell analysis market.
By Types of
cells: Human, Animal, Microbial
By Type of
technique: Mass Spectroscopy (MS), Polymerase Chain Reaction
(PCR), Next-Generation Sequencing, Flow Cytometry, Microscopy,
Adoption rate of
treatment options, for instance, stem cell therapy and in-vitro
fertilization (IVF) is increasing significantly.
Long shelf life of
single cell analysis products and consumable products is another
driver for the growth of single cell analysis market.
However, high cost
of instruments may have a negative impact on market growth in future.
Global
Single Cell Analysis Market – Trends and Opportunity
A study by the
Journal of Analytical and Bioanalytical Chemistry in 2014, stated
that Inductively Coupled Plasma Mass Spectroscopy (ICP-MS) and ICP
Optical Emission Spectrometry (ICP-OES) are applied using metal atoms
such as nanoparticle for investigation of cell-to-cell variance or
cellular uptake of drugs and other elements. Single-cell genomics
find many clinical applications such as genetic diagnosis of
embryo-related diseases and to study blood-borne Circulating Tumor
Cells (CTCs). These applications may be further employed for
diagnosis, prognosis, and treatment of cancer.
Major key players in
the global single cell analysis market include 10X Genomics, Abcam
Plc., Agilent Technologies, Fluxion Biosciences, Becton, Dickinson
and Company, Bio-Rad Laboratories, Inc., Bio-Techne Corporation,
Bruker, Danaher Corporation, Fluidigm Corporation, GE Healthcare, and
Illumina, among others.
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Cell Analysis Market
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